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Search Results for " complement C5 "

ターゲット

16

阻害剤

26

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T10863 Complement C5-IN-1 Complement System
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
T9915 Eculizumab Complement System
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
T76867 Ravulizumab ALXN1210 Complement System
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo...
T77022 Gefurulimab
Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin. It specifically binds to C5, inhibiting its activation [1].
T74431 Cemdisiran
Cemdisiran, a conjugated siRNA with N-acetylgalactosamine (GalNAc), targets the liver to inhibit the production of complement 5 (C5) protein, serving as a potential therapeutic agent for the study of complement-mediated ...
T75106 ARC186
ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.
T74551 Avacincaptad pegol sodium
Avacincaptad pegol (ARC1905), an anti-C5 RNA aptamer, prevents the cleavage of complement factor 5 (C5) into fragments C5a and C5b. It is currently under investigation for the treatment of age-related macular degeneratio...
T76276 Zilucoplan
Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor, is utilized in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].
T74550 Cemdisiran, terminal sugar modification-
Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA,...
T74552 Non-PEGylated/naked ARC1905
ARC1905, a non-PEGylated/naked anti-C5 RNA aptamer, functions by inhibiting the cleavage of complement factor 5 (C5) into its components, C5a and C5b, without PEG conjugation. This compound is currently being researched ...
T77121 Pozelimab
Pozelimab (REGN3918), a fully human IgG4 monoclonal antibody, is designed to target and bind with high affinity to both C5 and its variants, effectively inhibiting complement-mediated hemolysis. It holds potential for re...
T77190 Crovalimab
Crovalimab (SKY59; RO7112689) is a novel humanized antibody designed to target C5 in a pH-dependent manner, demonstrating binding affinities (KD) of 15.2 nM and 16.8 μM at pH levels of 7.4 and 5.8, respectively. Addition...
T80083 Zilucoplan TFA RA101495 TFA Complement System
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].
T78191 NH2-C6-ARC186 Complement System
NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement inhibitor, it operates by inhibiting convertase-mediated C5 a...
T77163 Pexelizumab
Pexelizumab (h5G1.1-SC), a humanized scFv monoclonal antibody, targets the C5 complement component, thereby inhibiting apoptosis and leukocyte infiltration. It is utilized in researching cerebral ischemia-reperfusion (IR...
T74699 Avacincaptad pegol
Avacincaptad pegol, a pegylated aptamer, stands out as an effective C5 complement inhibitor capable of mitigating inflammation-induced damage to the retinal pigment epithelium (RPE). This compound is under investigation ...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-00653 Complement C5 Protein, Human, Recombinant (Complement C5a) Human E. coli
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-05057 Complement C5 Protein, Human, Recombinant (His & FLAG) Human HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPH-03270 Complement C5 Protein, Rat, Recombinant (His & Myc) Rat E. coli
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the founda...
TMPY-06814 Complement C5 Protein, Human, Recombinant (Flag) Human HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-06538 Complement C5 Protein, Cynomolgus, Recombinant Cynomolgus HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPH-03107 Complement C5a Protein, Pig, Recombinant (His) Sus scrofa (Pig) Yeast
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, ...
TMPY-06137 Complement C5 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPK-01268 Complement C2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to health...
TMPH-02607 Complement factor B Protein, Mouse, Recombinant (His) Mouse E. coli
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert...
TMPY-00686 Complement C2 Protein, Human, Recombinant (His) Human HEK293
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext...
TMPY-04902 Complement C5a Protein, Mouse, Recombinant Mouse E. coli
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPH-03038 Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Naja kaouthia E. coli
Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to fo...
TMPH-02844 Properdin Protein, Mouse, Recombinant (His) Mouse E. coli
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPH-02845 Properdin Protein, Mouse, Recombinant (His & Myc) Mouse HEK293
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPJ-00149 Complement Factor D/CFD Protein, Mouse, Recombinant (His) Mouse Human Cells
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a...
TMPH-02605 Complement C4-B Protein, Mouse, Recombinant (His) Mouse E. coli
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of imm...
TMPJ-00585 Complement C8 gamma Protein, Human, Recombinant (His) Human E. coli
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 ...
TMPY-03004 CD55/DAF Protein, Rat, Recombinant (hFc) Rat HEK293
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It...
TMPY-02616 CD55/DAF Protein, Mouse, Recombinant (His) Mouse HEK293
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It...
TMPY-01292 CD55/DAF Protein, Human, Recombinant (His) Human HEK293
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It...
TMPY-00713 CD55/DAF Protein, Human, Recombinant (hFc) Human HEK293
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It...
TMPY-06679 CD55/DAF Protein, Mouse, Recombinant (hFc) Mouse HEK293
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It...
TMPY-03447 Complement C2 Protein, Mouse, Recombinant (His) Mouse HEK293
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext...
TMPY-00687 Complement C2 Protein, Human, Recombinant (hFc) Human HEK293
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext...
TMPH-01870 Plasminogen Protein, Human, Recombinant (His) Human E. coli
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the...
TMPY-05459 Complement C5a Protein, Mouse, Recombinant, Biotinylated Mouse E. coli
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
Complement C5 Protein, Human, Recombinant (Complement C5a)
TMPY-00653
Species: Human
Expression System: E. coli
Complement C5 Protein, Human, Recombinant (His & FLAG)
TMPY-05057
Species: Human
Expression System: HEK293
Complement C5 Protein, Rat, Recombinant (His & Myc)
TMPH-03270
Species: Rat
Expression System: E. coli
Complement C5 Protein, Human, Recombinant (Flag)
TMPY-06814
Species: Human
Expression System: HEK293
Complement C5 Protein, Cynomolgus, Recombinant
TMPY-06538
Species: Cynomolgus
Expression System: HEK293
Complement C5a Protein, Pig, Recombinant (His)
TMPH-03107
Species: Sus scrofa (Pig)
Expression System: Yeast
Complement C5 Protein, Cynomolgus, Recombinant (His)
TMPY-06137
Species: Cynomolgus
Expression System: HEK293
Complement C2 Protein, Cynomolgus, Recombinant (His)
TMPK-01268
Species: Cynomolgus
Expression System: HEK293
Complement factor B Protein, Mouse, Recombinant (His)
TMPH-02607
Species: Mouse
Expression System: E. coli
Complement C2 Protein, Human, Recombinant (His)
TMPY-00686
Species: Human
Expression System: HEK293
Complement C5a Protein, Mouse, Recombinant
TMPY-04902
Species: Mouse
Expression System: E. coli
Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)
TMPH-03038
Species: Naja kaouthia
Expression System: E. coli
Properdin Protein, Mouse, Recombinant (His)
TMPH-02844
Species: Mouse
Expression System: E. coli
Properdin Protein, Mouse, Recombinant (His & Myc)
TMPH-02845
Species: Mouse
Expression System: HEK293
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
TMPJ-00149
Species: Mouse
Expression System: Human Cells
Complement C4-B Protein, Mouse, Recombinant (His)
TMPH-02605
Species: Mouse
Expression System: E. coli
Complement C8 gamma Protein, Human, Recombinant (His)
TMPJ-00585
Species: Human
Expression System: E. coli
CD55/DAF Protein, Rat, Recombinant (hFc)
TMPY-03004
Species: Rat
Expression System: HEK293
CD55/DAF Protein, Mouse, Recombinant (His)
TMPY-02616
Species: Mouse
Expression System: HEK293
CD55/DAF Protein, Human, Recombinant (His)
TMPY-01292
Species: Human
Expression System: HEK293
CD55/DAF Protein, Human, Recombinant (hFc)
TMPY-00713
Species: Human
Expression System: HEK293
CD55/DAF Protein, Mouse, Recombinant (hFc)
TMPY-06679
Species: Mouse
Expression System: HEK293
Complement C2 Protein, Mouse, Recombinant (His)
TMPY-03447
Species: Mouse
Expression System: HEK293
Complement C2 Protein, Human, Recombinant (hFc)
TMPY-00687
Species: Human
Expression System: HEK293
Plasminogen Protein, Human, Recombinant (His)
TMPH-01870
Species: Human
Expression System: E. coli
Complement C5a Protein, Mouse, Recombinant, Biotinylated
TMPY-05459
Species: Mouse
Expression System: E. coli